PRP (Platelets Rich Plasma- Platelet/Platelet Enriched Plasma)

The practice was first started by dentists years ago. Their goal was to create stronger gingival tissue so that they could place titanium implants in the gums of older patients.

The purpose of PRP is to prepare platelet-rich plasma concentrate in whole blood by using special centrifuge and laboratory kits.

As it is known, platelets provide regeneration by being transported to the damaged tissue by blood in case of any tissue damage or injury. With 60 different growth factors in them, they work in a certain order in the process of repairing tissue damage. When these factors are created and given correctly, they contribute to tissue regeneration at a very high rate.

Our main goal in separating platelets is to send the following growth factors to the parts where we expect regeneration:

PDGF (Platelet Derived Growth Factor): Main mitogen (vessel repair and formation), collagen + structural protein production for connective tissue cells and some special cells

IGF (Insulin-like Growth Factor): The main regulator for cell metabolism and growth (tissue repair), stimulates proliferation and differentiation in osteoblasts, collagen and hyaluronic acid production

EGF (Epidermal Growth Factor): Epidermal cell formation and wound healing

TGF (Transforming Growth Factor/ alpha, beta): Cell proliferation, differentiation and apoptosis. Ensuring epithelial and vascular epithelium wound healing

Apart from these, PRP; accelerates endothelial, epithelial, epidermal regeneration and angiogenesis; Provides collagen synthesis. It creates an antimicrobial effect with a high leukocyte concentration. It has prolotherapy, that is, pain relieving effect. Since it is the person’s own blood, it has no side effects.

In practical application,
An appropriate amount of blood is taken from the patient on the anticoagulant taken into the injector. The collected blood is transferred to the PRP separation tube. Whole blood is separated by a programmed centrifuge to separate PRP. Within this program, it is ensured that the tubes reach the appropriate cycle, remain at the desired speed for a certain period of time, and then gradually slow down again. Dissociated blood products are taken from the tube removed from the device with a closed system kit.
Calcium chloride is added for activation during application and injection is made.

With the application of platelet-rich plasma (PRP);

• Gonarthrosis
• Lateralepicondylitis
• Heel spur
• Hip and knee osteoarthritis and injuries
• Bone fractures
• Tears in the shoulder joint and in the knee joint, partial tears of the meniscus and anterior-posterior cruciate ligaments
• Pain related to the jaw joint
• Arthritis
• Tendinitis
• Sports injuries
• Regeneration applications in aesthetic areas
• Burn treatment
• Alopecia areata
• Diabetic wounds
• Dentistry
• Plasma eye drops are used in diseases.

Contraindications:
Basically, PRP contraindications that may occur in cases of blood and platelet deficiency can be listed as follows:

• Coagulopathy
• Lack of platelet function
• Anemia
• Thrombocytopenia
• Hemodynamic instability
• Severe hypovolemia
• Sepsis
• Anticoagulant/fibrinolytic drug therapy
• Cancer patients

According to the amount obtained, PRP should be mixed with the activator at certain ratios (10% calcium chloride).